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US 4,791,132 AGranted
Phenyl, Pyrrolidin-2-yl substituted pyrroles having antipsychotic properties
AssigneeDuphar International Research B.V.
InventorsIneke Van Wijngaarden, Cornelis G. Kruse, Roelof Van Hes, Johannes A. M. Van Der Heyden
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Abstract
The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula ##STR1## wherein A is an unsaturated heterocyclic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent. The compounds have interesting pharmacological, notably antipsychotic properties.
Claims4
A compound of formula 1, ##STR5## wherein:
- R is hydrogen or alkyl having 1-3 carbon atoms;
- R.sub.1 is straight or branched alkyl having 1-4 carbon atoms;
- R.sub.2 is hydrogen;
- R.sub.3 is halogen or alkyl sulfonyl having 1-3 carbon atoms;
- n is 0-2;
- A is pyrrole, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent;
- or an acid addition salt or prodrug thereof.
4 more elements
Dependencies are inferred from the claim text.