Analgesic and antiinflammatory 1-acyl-2-oxindole-3-carboxamides
AssigneePfizer Inc.
InventorSaul B. Kadin
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Abstract
Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for acute administration for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and also for chronic administration for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
Claims9
A 1-acyl-2-oxindole-3-carboxamide compound of the formula ##STR10## and the pharmaceutically-acceptable base salts thereof;
- wherein X and Y are each selected from the group consisting of hydrogen, fluoro, chloro, bormo, trifluoromethyl and alkyl having 1 to 4 carbons;
- R.sup.1 is selected from the group consisting of heterocyclic, mono-methyl heterocyclic, furymethyl and thienylmethyl;
- wherein said heterocyclic is selected form the group consisting of pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl and isoxazolyl;
- and R.sup.2 is alkyl having 1 to 6 carbons.
Dependencies are inferred from the claim text.