Mitomycin derivatives as antileukemia agents
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsTokuyuki Kuroda, Koji Hisamura, Tohru Sugaya, Yutaka Ohsawa, Hideo Ueno, Makoto Morimoto, Tadashi Ashizawa
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Abstract
Mitomycin derivatives having potent antitumour activity have the formula: ##STR1## wherein R represents lower alkyl, cycloalkyl or unsubstituted or substituted aralkyl; X represents hydrogen or carbamoyl; Y and Z each independently represents hydrogen or methyl; and represents an .alpha. or .beta. bond.
Claims11
Mitomycin compounds represented by the formula:
- ##STR13## wherein R is selected from a member of the group consisting of a straight or branched alkyl having 1 to 6 carbon atoms, a cycloalkyl having 3 to 6 carbon atoms, benzyl, substituted benzyl wherein said substituent is selected from hydroxyl, methoxy, halogen, amino, nitro and C.sub.1 to C.sub.6 alkyl;
- phenethyl, diphenylmethyl and trityl;
- X is selected from hydrogen and carbamoyl;
- each of Y and Z is independently selected from hydrogen and methyl;
- and is selected from .alpha. and .beta. bonds.
[1aS-(1a.alpha., 8.beta., 8a.alpha., 8b.alpha.)] -8- {[(aminocarbonyl)-oxy]methyl} -6- [(isobutyloxy) imino] -8a- methoxy-5-methyl-1, 1a,2,5,6,8,8a,8b-octahydro-azirino-[2',3':3,4]-pyrrolo -[1,2-a] indole-4.7-dione.
[1aS-(1a.alpha., 8.beta., 8a.alpha.,8b.alpha.)]-8-{[(aminocarbonyl)oxy]methyl} -6- [(sec-butyloxy) imino] 8a-methoxy--5-methyl-1,1a,2,5,6,8,8a,8b -octahydro-azirino-[2',3':3,4]-pyrrolo [1,2-a] indole -4,7-dione.
[1aS-(1a.alpha., 8.beta., 8a.alpha.,8b.alpha.)]-8- hydroxymethyl-6-[(isobutyloxy) imino]-8a-methoxy-5methyl-1,1a2,5,6,8,8a,8b-octahydro-azirino- [2', 3':3,4] pyrrolo [1,2-a] indole-4,7-dione.
[1aS-(1a.alpha., 8.beta., 8a.alpha.,8b.alpha.)] -8 -{[(aminocarbonyl)oxy]methyl} -6-[(n-butyloxy) imino] -8a- methoxy-5- methyl-1,1a,2,5,6,8,8a,8b-octahydro-azirino [2',3':3,4]pyrrolo [1,2-a] indole-4,7-dione.
[1aS-(1a.alpha., 8.beta., 8a.alpha.,8b.alpha.)] -8-{[(aminocarbonyl)oxy]-methyl}-1,5-dimethyl-6-[(iso-butyloxy) imino]-8a-methoxy-1,1a,2,5,6,8, 8a,8b-octahydro-azirino-[2',3':3,4] pyrrolo [1,2-a] indole-4,7-dione.
Dependencies are inferred from the claim text.