1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents
AssigneePfizer Inc.
InventorSaul B. Kadin
Life of this patent
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Abstract
1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
Claims6
A 1,3-dicarboxamidooxindole compount of the formula ##STR308## and a pharmaceutically-acceptable base salt thereof, wherein X is selected from the group consisting of hydrogen, fluoro, chloro, bromo alkyl having one to four carbon atoms, alkythio having one to four carbon atoms, alkoxy having one to four carbons atoms, cycloalkyl having three to six carbon atoms, nitro, trifluoromethyl, acetyl, propionyl, butryl, benzoyl and thenoyl;
- Y is selected from the group consisting of hydrogen, fluoro, chloro, bromo, alkyl having one to four carbon atoms, alkoxy having one to four carbon atoms and alkylthio having one to four carbon atoms;
- X and Y when taken together are selected from the group consisting of 4,5-, 5,6- and 6,7-methylenedioxy;
- R.sub.1 is selected from either (1) heterocyclic and mono-methylated heterocyclic, wherein said heterocyclic is selected from the group consisting of pyridyl, thienyl, furyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl and isoxazolyl;
- or (2) furylmethyl and thienylmethyl;
- and R.sub.2 is hydrogen.
The compound of claim 12, wherein R.sub.1 is 2-thienyl, X is 5-chloro and Y is hydrogen.
Dependencies are inferred from the claim text.