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US 4,791,128 AGranted
Rhizoxin esters and salts, their pharmaceutical use as anti-tumor agents
AssigneeSankyo Company, Limited
InventorsShigenobu Okuda, Shigeo Iwasaki, Michio Namikoshi, Masao Arakawa, Fusaaki Shimizu
Life of this patent
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Abstract
Acylated derivatives of rhizoxin and of rhizoxin-2-ene may be prepared by reacting rhizoxin or rhizoxin-2-ene with an acid or reactive derivative thereof. They have excellent anti-tumor activity.
Claims27
A compound of formula (I):
- ##STR11## wherein:
- R represents an alkyl group having 2-30 carbon atoms;
- and
- A represents an extra carbon-carbon bond or an oxygen atom,
- and pharmaceutically acceptable salts and ring-closed lactones thereof.
2 more elements
A compound of formula (II):
- ##STR12## wherein:
- R represents an alkyl group having 2-30 carbon atoms;
- and
- A represents an extra carbon-carbon bond or an oxygen atom.
1 more element
A pharmaceutical composition comprising an anti-tumor agent in admixture with a pharmaceutically acceptable carrier or diluent, wherein the anti-tumor agent is selected from the group consisting of compounds of formula (I):
- ##STR13## wherein:
- R represents an alkyl group having 2-30 carbon atoms;
- and
- A represents an extra carbon-carbon bond or an oxygen atom,
- and pharmaceutically acceptable salts and ring-closed lactones thereof.
2 more elements
Dependencies are inferred from the claim text.