4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
AssigneeThe BOC Group, Inc.
InventorsLinas V. Kudzma, H. Kenneth Spencer, Sherry A. Severnak
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Abstract
Compounds are disclosed of the formula ##STR1## where R.sup.2 is unsubstituted or substituted phenyl, R.sup.3 is lower alkyl, lower cycloalkyl or lower alkoxy lower alkyl, and L is selected from a wide variety of groups. This new class of compounds exhibit improved analgesic and anesthetic properties.
Claims10
A compound of the formula ##STR16## optically active isomeric forms thereof, or pharmaceutically acceptable acid addition salts thereof, in which formula:
- R.sup.1 is phenyl;
- R.sup.2 is phenyl unsubstituted or substituted with one or more halogens;
- R.sup.3 is a lower alkyl, lower cycloalkyl or a lower alkoxy lower alkyl;
- and L is (4,5-dihydro-5-oxo-1H-tetrazol-1-yl) lower alkyl which is unsubstituted or substituted in the 4-position with a lower alkyl.
A narcotic antagonistic or analgesic composition consisting of a non-toxic pharmaceutically acceptable carrier and therapeutically effective amount of a compound of the formula ##STR17## optically active isomeric forms thereof, or pharmaceutically acceptable acid addition salts thereof, in which formula:
- R.sup.1 is phenyl;
- R.sup.2 is phenyl unsubstituted or substituted by one or more halogens;
- R.sup.3 is a lower alkyl, lower cycloalkyl or a lower alkoxy lower alkyl;
- and L is (4,5-di-hydro-5-oxo-1H-tetrazol-1-yl) lower alkyl which is unsubstituted or substituted in the 4-position with a lower alkyl.
A method for providing analgesia or anesthesia in a mammal, consisting of administrating to such mammal an analgesically or anesthetically effective amount of a compound of the formula ##STR18## optically isomeric forms thereof, or pharmaceutically acceptable acid addition salts thereof, in which formula:
- R.sup.1 is phenyl;
- R.sup.2 is phenyl unsubstituted or substituted with one or more halogens;
- R.sup.3 is a lower alkyl, lower cycloalkyl or a lower alkoxy lower alkyl;
- and L is (4,5-di-hydro-5-oxo-1H-tetrazol-1-yl) lower alkyl which is either unsubstituted or substituted in the 4-position with a lower alkyl.
Dependencies are inferred from the claim text.