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US 4,791,117 AGranted
2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
AssigneeOrtho Pharmaceutical Corporation
InventorJeffery B. Press
Life of this patent
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Abstract
Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.
Claims4
A method for blocking calcium channels of a mammal which comprises administering to a mammal an effective amount of a compound of the formula ##STR7## where X is hydrogen, halogen, hydroxy, alkoxy, having 1--3 carbon atoms, benzyloxy, or C.sub.1 -C.sub.6 alkyl, either singularly or in combination;
- R is H or Ar;
- R.sub.1 is H, CH.sub.3 or Ar;
- Ar is ##STR8## R.sub.2 is C.sub.1 -C.sub.6 alkyl;
- N is 0 or 1 when R is Ar or 1 when R.sub.1 is Ar;
- and
- m is 2-6, with the proviso that both R and R.sub.1 are not Ar at the same time and at least one of R and R.sub.1 is Ar.
3 more elements
Dependencies are inferred from the claim text.