Dihydrobenzothiophene and thiochromane aminoalcohols
AssigneeMaggioni-Winthrop S.p.A.
InventorsGiampaolo Picciola, Mario Riva, PierGiuseppe De Meglio, Piergiorgio Gentili
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Abstract
The invention is concerned with dihydrobenzothiophene and thiochromane derivatives of the generic formula ##STR1## The compounds show anti-hypertensive, platelet aggregation inhibiting, hypolipemic, antianoxic spasmolytic, anthithrombotic, calcium antagonizing and neuroleptic activity.
Claims9
A compound of the formula ##STR10## in its cis and trans configuration and mixtures thereof, wherein R and R.sub.1 represent hydrogen or a lower alkyl group, n represents an integer selected from 1 and 2, and R.sub.2 represents a divalent radical selected from
- (a) ##STR11## wherein Y represents hydrogen or halogen;
- (b) ##STR12## wherein A is a group selected from ##STR13## wherein R.sub.4 represents a lower alkyl group;
- (c) ##STR14## and (d) ##STR15## wherein W represents a 2-furoyl radical or a group ##STR16## wherein X represents a group selected from --CH.dbd.CH--, --O-- and --S--, Z represents a hydrogen, halogen or a lower alkyl or alkoxy group and m is an integer from 1 to 3, and their salts with inorganic acids, organic acids, or cationic exchange resins and complexes with cyclodextrins.
A compound selected from the stereoisomeric threo and erythro form of 1-(6-thiochromanyl)-2-[4-(1-oxo-3-phenyl-2-propenyl)-1-piperazinyl]-propan ol and their mixtures.
A compound selected from the stereoisomeric threo and erythro form of 1-(6-thiochromanyl)-2-(4-benzamido-1-piperdinyl)-propanol and their mixtures.
A compound selected from the stereoisomeric threo and erythro form of 1-(6-thiochromanyl)-2-[4-(oxo-1-benzimidazolinyl)-1-piperidinyl]-propanol and their mixtures.
A compound selected from the stereoisomeric threo and erythro form of 1-(2,3-dihydro-5-benzo[b]-thienyl-2-[4-(1-oxo-3-phenyl-2-propenyl)-1-piper azinyl]-propanol and their mixtures.
A compound selected from the stereoisomeric threo and erythro form of 1-(2-methyl-6-thiochromanyl)-2-[4-(1-oxo-3-phenyl)-1-piperazinyl]-propanol .
A compound of the formula:
- ##STR19## wherein Z is hydrogen, halogen, lower alkyl or lower alkoxy, R and R.sub.1 represent hydrogen or a lower alkyl group, m is an integer from 1 to 3 and n is 1 or 2, salts of said compound with inorganic acids, organic acids or cationic exchange resins and complexes of said compound with cyclodextrins.
Dependencies are inferred from the claim text.