2,N.sup.6 -disubstituted adenosines, derivatives and methods of use

A compound of the formula

• wherein R.sub.1 is of the formula ##STR3## wherein n is one to four;
• Y is hydrogen, lower alkyl, or OR where R is hydrogen, lower alkyl or lower alkanoyl;
• A is a bond or a straight or branched alkylene of one to four carbon atoms, inclusive with the proviso that A cannot be a bond when R.sub.1 is of Formula II and n is one;
• X and X' are each independently hydrogen, lower alkyl, lower alkoxy, hydroxy, lower alkanoyl, nitro, trifluoromethyl, halogen, amino, monoloweralkyl or diloweralkylamino, or when taken together a methylenedioxy group;
• R.sub.2 is (a) hydrogen, (b) halogen, (c) NR'R" where R' and R" are independently hydrogen, lower alkyl, phenyl, or phenyl substituted by lower alkyl, lower alkoxy, halogen, or trifluoromethyl, (d) SR'" where R'" is hydrogen, lower alkyl, lower alkanoyl, benzoyl, or phenyl;
• R'.sub.2, R'.sub.3, and R'.sub.5 are each independently hydrogen, alkanoyl having two to twelve carbon atoms, inclusive, in a straight or branched alkyl chain, benzoyl, or benzoyl substituted by lower alkyl, lower alkoxy, halogen, or R'.sub.2 and R'.sub.3 taken together are a five-membered ring having a total of up to twenty carbons;
• or R'.sub.5 is independently a phosphate, hydrogen, or dihydrogen phosphate, or an alkali metal or ammonium, or dialkali or diammonium salt thereof;
• its diastereomer;
• or a pharmaceutically acceptable acid addition salt thereof;
• with the proviso that overall when R.sub.1 is II and X, X', Y, and Z are hydrogen, or lower alkyl then n cannot be two.