Synergistic mixtures of interferons and tumor necrosis factor
AssigneeBoehringer Ingelheim GmbH
InventorGunther Adolf
Life of this patent
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Abstract
Ternary compositions of an interferon of the alpha and/or beta type with an interferon of the gamma type and tumor necrosis factor having a surprising and unexpected synergistic anti-proliferative effect on neoplastic cells when compared to the activity of the individual components of this invention, said compositions being useful in the treatment of neoplasia in animals including humans.
Claims27
A composition having a synergistic anti-proliferative effect on neoplastic animal cells, comprising a synergistically effective amount of
- (a) highly purified tumor necrosis factor;
- (b) highly purified type I interferon;
- and
- (c) highly purified type II interferon.
A composition having a synergistic anti-proliferative effect on neoplastic animal cells selected from the group consisting of anal, breast, cervical, colorectal, head, lung, melanoma, and neck cancer cells, comprising a synergistically effective amount of
- (a) highly purified tumor necrosis factor;
- (b) highly purified type I inerferon;
- and
- (c) highly purified type II interferon.
A method for the treatment of neoplastic disease in animals, comprising administering to an animal suffering from or suspected or suffering from said disease a synergistically effective amount of
- (a) highly purified tumor necrosis factor;
- (b) highly purified type I interferon;
- and
- (c) highly purified type II interferon.
A method for the treatment of neoplastic disease selected from the group consisting of anal, breast, cervical, colorectal, head, lung, melanoma, and neck cancer, comprising administering to an animal suffering from or suspected of suffering from said disease a synergistically effective amount of
- (a) highly purified tumor necrosis factor;
- (b) highly purified type I interferon;
- and
- (c) highly purified type II interferon.
Dependencies are inferred from the claim text.