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US 4,791,100 AGranted
Novel polypeptides with a blood coagulation-inhibiting action, processes for their preparation and isolation, their use and agents containing them
AssigneeHoechst Aktiengesellschaft
InventorsMartin Kramer, Dominique Tripier
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Abstract
The invention relates to a polypeptide of the formula ##STR1## in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.
Claims10
A polypeptide of the formula I
- wherein
- R represents a phenolic hydrogen or a phenolic ester group,
- A represents Ile or the absence of an amino acid,
- B represents Ile or Thr, or the absence of an amino acid,
- C represents Thr, Val, Ile, Leu or Phe,
- D represents Glu or the absence of an amino acid,
- E represents Glu or Pro,
- F represents Thr or Ile,
- G represents Lys or Lys-Asp,
- I represents Ala or Leu and
- J represents Gln or Lys,
- provided that when A and B represent the absence of an amino acid, D represents the absence of an amino acid, E represents Pro, F represents Ile, G represents Lys-Asp, I represents Ala, or J represents Lys and wherein ##STR8## are linked in pairs via disulfide bridges, or a physiologically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.