Polyionene transformed modified polysaccharide supports
AssigneeCuno Incorporated
InventorsKenneth C. Hou, Chung-Jen Hou, Haunn-Lin Chen
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Abstract
Polyionene-transformed modified polymer-polysaccharide separation matrix and use thereof in removing contaminants of microorganism origin from biological liquids are disclosed.
Claims55
A polyionene-transformed modified polysaccharide separation matrix comprising a modified polysaccharide having a synthetic polymer covalently coupled thereto and a polyionene bonded to said modified polysaccharide.
A polyionene-transformed modified polysaccharide separation matrix which comprises:
- (1) polysaccharide covalently coupled to a synthetic polymer;
- (2) said synthetic polymer made from at least one of
- (a) a polymerizable compound which has a chemical group capable of direct or indirect covalent coupling to said polysaccharide;
- and
- (b) one or more polymerizable compounds containing
- (i) an ionizable chemical group,
- (ii) a chemical group capable of transformation to an ionizable chemical group,
- (iii) a chemical group capable of causing the covalent coupling of said synthetic polymer (2) to an affinity ligand or biologically active molecule, or
- (iv) a hydrophobic chemical group;
- said modified polysaccharide having bonded thereto, a polyionene.
A self-supporting cellulosic fibrous matrix comprising
- (1) cellulose covalently coupled to a synthetic polymer;
- and
- (2) a polyionene reactively bonded to said cellulose.
A method for removing and inactivating contaminants of a microorganism origin from a biological liquid comprising passing said liquid through a polyionene-transformed modified polysaccharide matrix wherein said modified polysaccharide matrix comprises
- (1) polysaccharide covalently coupled to a synthetic polymer;
- (2) said synthetic polymer made from at least one of
- (a) a polymerizable compound which has a chemical group capable of direct or indirect covalent coupling to said polysaccharide;
- and
- one or more polymerizable compounds containing
- (i) an ionizable chemical group,
- (ii) a chemical group capable of transformation to an ionizable chemical group,
- (iii) a chemical group capable of causing the covalent coupling of said compound (2) to an affinity ligand or biologically active molecule, or
- (iv) a hydrophobic chemical group;
- said modified polysaccharide having bonded thereto a polyionene, said polyionene comprising a water-soluble polymer having polyquaternary ammonium groups separated by hydrophobic groups, said hydrophobic groups comprising aromatic groups or alkyl groups, said alkyl groups containing at least six carbon atoms.
Dependencies are inferred from the claim text.