Process for the production of an N-protected-L-.alpha.-aspartyl-L-phenylalanine
AssigneeAjinomoto Co., Inc.
InventorsTadashi Takemoto, Toshihide Yukawa, Kunio Hisamitsu
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Abstract
A process is described for the synthesis of N-protected-L-.alpha.-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R.sub.1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R.sub.2, where R.sub.1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R.sub.2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.
Claims20
A process for producing a N-protected-L-.alpha.-aspartyl-L-phenylalanine compound, comprising:
- reacting a N-protected-L-aspartic anhydride and a L-phenylalanine salt in an aqueous medium, wherein said L-phenylalanine salt is an alkali metal salt, an alkaline earth metal salt, an organic amine salt, or an ammonium salt;
- and
- obtaining a N-protected-L-.alpha.-aspartyl-L-phenylalanine salt.
Dependencies are inferred from the claim text.