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US 4,789,750 AGranted
2-(trimethyl-tridecenyl)-tetramethylchroman intermediates for vitamin E
AssigneeHoffman-La Roche Inc.
InventorsDavid L. Coffen, Rudolf Schmid, Mark J. Sebastian
Life of this patent
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Abstract
6-Etherified hydroxy -2-(4',8',12'-trimethyl-5'-tridecenyl)-2,5,7,8-tetramethylchromans with an oxo or hydroxy substituent at the 2' position which may be substituted with an arylsulfonyl or a carboxyalkyl at the 3' position and containing a single or double bond at the 11 position, said chromans being intermediates for producing natural vitamin E.
Claims16
A compound of the formula:
- ##STR24## wherein R.sub.16 is hydrogen, --COOR.sub.4 or ##STR25## the dotted line forms either a saturated single or an unsaturated double bond;
- R.sub.3 taken together with its attached oxygen forms an ether hydroxy protecting group;
- R.sub.4 is lower alkyl and R.sub.6 is lower alkyl or aryl.
A compound of the formula:
- ##STR27## wherein R.sub.16 is ##STR28## R.sub.5 is hydrogen or lower alkyl;
- R.sub.6 is lower alkyl or aryl;
- R.sub.3 taken together with its attached oxygen atom forms an ether hydroxy protecting group;
- and the dotted line forms either a saturated single bond or an unsaturated double bond.
1 more element
Dependencies are inferred from the claim text.