Process for the resolution of enantiomeric aryloxyphenoxy propionates
AssigneeThe Dow Chemical Company
InventorJohn W. Russell
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Abstract
A process for the effective analytical or preparative resolution of the enantiomers of 2-(4-aryloxyphenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof which comprises converting a racemic or partially resolved mixture of said 2-(4-aryloxyphenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof to a pair of diastereomeric terpene esters by reaction with an optically active terpene alcohol and separating the diastereomers of the terpene ester by liquid chromatography with a silica column.
Claims3
A process for the resolution of the enantiomers of a 2-(4-aryloxyphenoxy)propionic acid of the formula ##STR10## wherein Ar is ##STR11## and X is CF.sub.3, F, Cl, Br or I and Y is H, F, Cl, Br or I
- or a C.sub.1 -C.sub.4 alkyl ester thereof which comprises converting a racemic or partially resolved mixture of said 2-(4-aryloxyphenoxy)propionic acid or C.sub.1 -C.sub.4 alkyl ester thereof to a pair of diastereomeric terpene esters by reaction with an optically active terpene alcohol and separating the diastereomers of the terpene esters by elution from a silica column with an eluent selected from the group consisting of hydrocarbons, halogenated hydrocarbons, water-saturated halogenated hydrocarbons and mixtures thereof.
Dependencies are inferred from the claim text.