Complexes of technetium-99m with propylene amine oximes
AssigneeAmersham International plc
InventorsLewis R. Canning, David P. Nowotnik, Rudi D. Neirinckx, Ian M. Piper
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Abstract
A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain.
Claims9
A lipophilic macrocyclic complex, useful as a diagnostic radiopharmaceutical, of technetium-99m with a propylene amine oxime ligand having the formula:
- ##STR9## said complex being in the form of a single stereoisomer or a mixture of stereoisomers.
A propylene amine oxime ligand having the formula:
- ##STR10## said ligand being in the form of a single stereoisomer or a mixture of stereoisomers.
Dependencies are inferred from the claim text.