US 4,789,683 AGranted

Benzamido-derivatives

AssigneeAstra Lakemedel Aktiebolag

InventorsGosta L. Florvall, Jan O. G. Lundstrom, Sten I. Ramsby, Sven O. gren

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Abstract

Novel therapeutically active compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group or an acyl group, R.sup.3 is a lower alkyl group; an alkenyl group; or a benzyl group optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl or lower alkoxy, A.sup.1 and A.sup.2 are the same or different and each represents a hydrogen atom, a lower alkyl group, an acyl group, an alkoxycarbonyl group or a dialkylcarbamyl group, provided that when A.sup.1 and A.sup.2 are the same lower alkyl group and R.sup.3 is ethyl, R.sup.1 or R.sup.2 or both are selected among cyano, lower alkyl and acyl; or a physiologically acceptable salt or optical isomers thereof, methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.

Claims16

Dependent claims

A compound of formula ##STR39## wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms or an acyl group having the formula alkyl--CO-- wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms, R.sup.3 is a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms;

and alkenyl group which may be straight or branched and has from 2 to 5 carbon atoms and has at least one double bond;
or a benzyl group, wherein said benzyl group is optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl which may be straight or branched and has from 1 to 5 carbon atoms or lower alkoxy having the formula alkyl-O wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms or any combination thereof, one of A.sup.1 and A.sup.2 is a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms, and the other of A.sup.1 and A.sup.2 is a hydrogen atom;
or a physiologically acceptable salt or optical isomer thereof.

A compound of formula ##STR40## wherein R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms or an acyl group having the formula alkyl--CO-- wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms, R.sup.3 is a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms;

an alkenyl group which may be straight or branched and has from 2 to 5 carbon atoms and has at least one double bond;
or a benzyl group, wherein said benzyl group is optionally substituted with fluorine, chlorine, bromine, trifluoromethyl, lower alkyl which may be straight or branched and has from 1 to 5 carbon atoms or lower alkoxy having the formula alkyl-O wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms or any combination thereof, one of A.sup.1 and A.sup.2 is a lower alkyl group which may be straight or branched and has from 1 to 5 carbon atoms, and the other of A.sup.1 and A.sup.2 is an acyl group having the formula alkyl--CO-- wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms, or an alkoxycarbonyl group having the formula alkyl--O--CO-- wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms, or a dialkylcarbamyl group having the formula (alkyl).sub.2 --N--CO-- wherein the alkyl moiety is straight or branched and has from 1 to 5 carbon atoms;
or a physiologically acceptable salt or optical isomer thereof.

Dependencies are inferred from the claim text.

Facts

Application: 06/689,502Filed 8 Jan 1985 · continuation
Priority: SE 810153611 Mar 1981
Granted: 6 Dec 1988
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 207/09
With hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms: radicals substituted by nitrogen atoms, not forming part of…
A61P 1/08
Drugs for disorders of the alimentary tract or the digestive system: for nausea, cinetosis or vertigo; Antiemetics
A61P 25/18
Drugs for disorders of the nervous system: antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
C07D
Heterocyclic compounds