N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl]benzenesulphonamides
AssigneeJohn Wyeth and Brothers Limited
InventorsJohn T. A. Boyle, Richard S. Todd
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Abstract
New compounds having the formula I ##STR1## where one of A and B is CH or N, the other of A and B is CH, Q is lower alkylene, R is lower alkyl, X.sub.1 is halogen or trifluoromethyl and X.sub.2 and X.sub.3 are independently selected from hydrogen, halogen, trifluoromethyl, lower alkoxy and lower alkyl and the pharmaceutically acceptable acid additions are disclosed as anti-hypertensive agents. New compounds having the formula II ##STR2## where Q, R, X.sub.2 and X.sub.3 are as explained above and n is 0 or 1 and their acid addition salts are useful as intermediates.
Claims6
A compound selected from those having the formula I ##STR12## and their pharmaceutically acceptable acid addition salts, wherein Q is a straight or branched alkyl group of 1 to 6 carbon atoms;
- R is an alkyl group of 1 to 6 carbon atoms;
- X.sub.1 is selected from halogen and trifluormethyl;
- and X.sub.2 and X.sub.3 are independently selected from hydrogen, halogen, trifluoromethyl, alkyl of 1 to 6 carbon atoms and alkoxy of 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.