1.alpha.,7.alpha.-dithio-substituted spirolactones, processes for their preparation, and their use as medicines
AssigneeSchering Corporation
InventorsKlaus Nickisch, Henry Laurent, Dieter Bittler, Rudolf Wiechert, Wolfgang Losert
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Abstract
The disclosure relates to novel 1.alpha.,7.alpha.-dithio-substituted spirolactones of general Formula I ##STR1## wherein R.sup.1 is C.sub.1-3 -alkyl and C.sub.1-3 -acyl and R.sup.2 is hydrogen, C.sub.1-3 -alkyl and C.sub.1-3 -acyl, to their preparation, and to their use as medicinal agents. The compounds of this invention exhibit anti-aldosterone activity and show the profile of effectiveness of a pro-drug.
Claims14
1.alpha.,7.alpha.-Dithio-substituted spirolactone of general Formula I ##STR3## wherein R.sup.1 is C.sub.1-3 -alkyl or C.sub.1-3 -acyl and
- R.sup.2 is hydrogen or C.sub.1-3 -alkyl.
A 1.alpha.,7.alpha.-Dithio-substituted spirolactone of general Formula I ##STR4## wherein R.sup.1 is C.sub.1-3 -alkyl and
- R.sup.2 is C.sub.1-3 -acyl.
Dependencies are inferred from the claim text.