External pharmaceutical composition and methods of use
AssigneeTeijin Limited
InventorsYuji Makino, Hideo Matugi, Yoshiki Suzuki
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Abstract
A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising (A) a pharmaceutically effective amount of the pharmacologically active agent, and (B) an optically active or inactive pyroglutamate of the following formula ##STR1## wherein R represents a linear, branched or cyclic alkyl or alkenyl group having 10 to 14 carbon atoms, as a penentration enhancer.
Claims14
A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising
- (A) an effective amount of an anti-inflammatory agent selected from the group consisting of salicylic acid, indomethacin, and betamethasone valerate and
- (B) an effective amount of an optically active or inactive pyroglutamate of the following formula ##STR8## wherein R represents a linear, branched or cyclic alkyl or alkenyl group having 10 to 14 carbon atoms, as a penetration enhancer.
In a method of enhancing the penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, the improvement which comprises externally applying to the skin or mucosa an effective amount of an optically active or inactive pyroglutamate in an amount sufficient to enhance said penetration, said pyroglutamate having the following formula:
- ##STR9## wherein R represents a linear, branched or cyclic alkyl or alkenyl group having 10 to 14 carbon atoms.
Dependencies are inferred from the claim text.