Method and composition for in vivo radiolabeling of red blood cells with .sup.99m Tc
OwnerMichael H. Davisinventor
Life of this patent
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Abstract
A composition containing stannous chloride and potassium perchlorate is suitable for oral administration to a patient for tinning red blood cells of the patient in vivo prior to labeling the red blood cells with radioactive .sup.99m Tc. The composition is useful for preparing a patient for blood pool imaging, and especially for carrying out equilibrium gated cardiac imaging.
Claims26
A pill in the form of a tablet or capsule suitable for oral administration to a patient for tinning red blood cells of the patient in vivo in preparation for radiolabeling the red blood cells with .sup.99m Tc, wherein said pill comprises a composition consisting essentially of
- (1) about 10 mg to about 200 mg stannous chloride, and
- (2) about 250 mg to about 1000 mg potassium perchlorate.
A method of treating a mammalian patient for tinning red blood cells in vivo, said method comprising
- orally administering to the patient about 8.9 mg/kg body weight to about 10 mg/kg body weight of a composition consisting essentially of
- (1) about 10 mg to about 200 mg stannous chloride, and
- (2) about 250 mg to about 1000 mg potassium perchlorate;
- and
- incubating red blood cells in vivo for a time sufficient for Sn.sup.2+ to be absorbed by the red blood cells.
A method for radiolabeling red blood cells of a patient, said method comprising
- orally administering to the patient about 8.9 mg/kg body weight to about 42 mg/kg body weight of a composition consisting essentially of
- (1) about 10 mg to about 200 mg stannous chloride, and
- (2) about 250 mg to about 1000 mg potassium perchlorate;
- incubating red blood cells in vivo in the presence of Sn.sup.2+ for a time sufficient for tin to be absorbed by the red blood cells in the patient;
- contacting the resulting tinned red blood cells with .sup.99m Tc;
- and
- incubating the tinned red blood cells with the .sup.99m Tc for a time sufficient to radiolabel the cells.
A method of carrying out equilibrium blood pool imaging in a patient, said method comprising
- orally administering to the patient about 8.9 mg/kg body weight to about 42 mg/kg body weight of a composition consisting essentially of
- (1) about 10 to about 200 mg stannous chloride, and
- (2) about 250 mg to about 1000 mg potassium perchlorate;
- incubating red blood cells in vivo in the presence of Sn.sup.2+ for a time sufficient for tin to be absorbed by the red blood cells in the patient;
- contacting the resulting tinned red blood cells with .sup.99m Tc;
- and
- incubating the tinned red blood cells with the .sup.99m Tc for a time sufficient to radiolabel the cells;
- and
- imaging a blood pool of the patient with means for detecting and reporting radioactivity emitted by the .sup.99m Tc.
A kit for tinning red blood cells of a patient in vivo in preparation for radiolabeling the cells with .sup.99m Tc, wherein the kit contains a drug consisting essentially of
- (1) a solid, unit dose of stannous compound consisting essentially of about 10 mg to about 200 mg of stannous chloride sufficient to tin the red blood cells in vivo;
- and
- (2) a solid, unit dose of potassium perchlorate in an amount of about 250 mg to about 1000 mg sufficient to substantially inhibit absorption of .sup.99m Tc by the gut of a patient, while permitting the tinning of red blood cells and radiolabeling of red blood cells with .sup.99m Tc;
- wherein the stannous chloride and potassium perchlorate are in a weight ratio of about 1:5 to about 1:100.
Dependencies are inferred from the claim text.