Measurement of capillary flow using nuclear magnetic resonance
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsH. Samuel Patz, Robert C. Hawkes
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AssigneeThe Brigham and Women's Hospital, Inc.
InventorsH. Samuel Patz, Robert C. Hawkes
Estimating the term…
An improved method for measuring very slow flow rates using nuclear magnetic resonance techniques is disclosed. The basic technique is that of steady state free precession, in which a sequence of radio frequency pulses are applied to nuclei in a magnetic field having a substantial gradient, so that a driven equilibrium state is obtained and which is characterized by a spatial periodicity in the magnetization response of the nuclei. Two images are generated. The two images may be generated using different time intervals between the application of the radio frequency pulses. Alternatively, the two images may be generated using different effective gradients. The spatial periodicity, and the NMR response of flowing nuclei to the spatial periodicity, is thus different during the two image formations. One image is subtracted from the other, which cancels signals from static nuclei in the signal, while relatively fast flowing nuclei, namely in the larger blood vessels or the like, never reach the equilibrium state. The subtraction difference is therefore proportional only to nuclei which are part of relatively slowly flowing liquids, such as in capillary blood flow in organs.
A method for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained in said sample, said method comprising the steps of:
A method for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained in said sample, said method comprising the steps of:
A method for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained in said sample, said method comprising the steps of:
An apparatus for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained within said sample, said apparatus comprising:
An apparatus for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained within said sample, said apparatus comprising:
An apparatus for providing an image of a sample, wherein individual elements of said image have intensities corresponding to the quantity of slowly flowing fluids contained within said sample, said apparatus comprising:
Dependencies are inferred from the claim text.