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US 4,788,335 AGranted
Hypoglycemic N-(2-substituted-3-dialkylamino-2-propenylidene)-N-alkylalkanaminium salts
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsEugene R. Wagner, Donald P. Matthews, Charlotte L. Barney
Life of this patent
Estimating the term…
Abstract
N-(3-Dialkylamino-2-propenylidene)-N-alkylalkanaminium salts substituted in the 2-position with an ether or thioether and having the formula ##STR1## are active as hypoglycemic agents.
Claims4
A compound of the formula ##STR7## wherein R.sup.1 is methyl or ethyl;
- R.sup.2 represents a group of formula R.sup.3 S-- or R.sup.4 O--;
- R.sup.3 is selected from the group consisting of straight or branched chain alkyl having from 1 to 12 carbon atoms, straight or branched chain alkenyl having from 2 to 12 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, cycloalkylalkyl having from 4 to 10 carbon atoms, benzyl, or phenyl optionally substituted by from 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, hydroxy, benzyloxy, di(lower alkyl)amino, nitro, phenyl or benzyl, or by a single 2,3- or 3,4-methylenedioxy moiety;
- R.sup.4 represents cycloalkyl of from 3 to 8 carbon atoms, straight or branched chain alkyl or alkenyl of from 3 to 12 carbon atoms or cycloalkylalkyl of from 4 to 10 carbon atoms;
- An is a pharmaceutically acceptable anion;
- and m is an integer corresponding to the valence of the anion.
2 more elements
A compound of the formula ##STR8## wherein R.sup.1 is a methyl or ethyl;
- R.sup.3 is selected from the group consisting of straight or branched chain alkyl having from 1 to 12 carbon atoms, straight or branched chain alkenyl having from 2 to 12 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, cycloalkylalkyl having from 4 to 10 carbon atoms, benzyl, or phenyl optinally substituted by from 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, hydroxy, benzyloxy, di(lower alkyl)amino, nitro, phenyl or benzyl, or by a single 2,3- or 3,4-methylenedioxy moiety;
- An is a pharmaceutically acceptable anion;
- and m is an integer corresponding to the valence of the anion.
Dependencies are inferred from the claim text.