Substituted butanamido acetate compounds for the preparation of pyrrolidone derivatives
AssigneeI.S.F. Societa per Azioni
InventorsMario Pinza, Ugo C. Pfeiffer
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Abstract
A process for preparing compounds (1) ##STR1## where Y is NR.sup.1 R.sup.2 or OR, R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl, and R is C.sub.1-3 alkyl, which comprises protecting the hydroxy group of a compound (2) ##STR2## cyclizing the product under basic conditions and removing the protecting group.
Claims3
A compound of structure (5) ##STR7## in which X is chloro or bromo, Y is NR.sup.1 R.sup.2 or OR where R.sup.1 and R.sup.2, which can be the same or different, are hydrogen or C.sub.1-3 alkyl and R is C.sub.1-3 alkyl, and R.sup.3 is hydrogen or a hydroxy-protecting group which is tetrahydropyranyl or .alpha.-ethoxyethyl.
A compound of claim 3 selected from:
- (i) methyl or ethyl 2-(4-bromo-3-hydroxybutanamido)acetate
- (ii) methyl or ethyl 2-(4-bromo-3-(tetrahydropyran-2-yloxy)butanamido) acetate
- (iii) ethyl 2-(4-chloro-3-hydroxybutanamido)acetate
- (iv) ethyl 2-(4-chloro-3-(tetrahydropyran-2-yloxy)butanamido)acetate.
Dependencies are inferred from the claim text.