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US 4,788,294 AGranted
Process for the production of 4-alkoxy-3-pyrrolin-2-ones
AssigneeLonza Ltd.
InventorsLaurent Duc, John McGarrity, Thomas Meul
Life of this patent
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Abstract
Process for the production of 4-alkoxy-3-pyrrolin-2-ones, which are preferred intermediate products for the production of cerebrally-active pharmaceutical products.
Claims1
In the process for the production of a 4-alkoxy-3-pyrrolin-2-one having the formula:
- ##STR2## wherein R.sub.1 is a C.sub.1 or C.sub.2 alkyl, consisting of the ammonolysis of 4-halo-3,3-di-[(C.sub.1 -C.sub.2)-alkoxy]-butyric acid-(C.sub.1 -C.sub.4)-alkyl ester, the improvement of effecting said ammonolysis by contacting said 4-alkoxy-3-pyrrolin-2-one and an aqueous ammonia solution having an NH.sub.3 content of 10 to 25 percent at a temperature of 20.degree. to 100.degree. C.
Dependencies are inferred from the claim text.