Medicinal uses for podophyllotoxins
AssigneeConpharm AB
InventorsKurt Leander, Borje Rosen
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Abstract
The invention relates to compounds consisting of podophyllotoxin and its derivatives of the formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is H or CH.sub.3, for treatment of psoriasis, malaria and rheumatoid arthritis and to a method for their preparation. Furthermore, the invention concerns the use of the compounds for treatment of said states of illness, as well as the use of said compounds for the preparation of pharmacological compositions for the treatment of said states of illness.
Claims5
A method of treating psoriasis which comprises administering to a host in need thereof, an antipsoriasis effective amount of a compound having the formula:
- ##STR3## wherein R.sub.1 is H or OH and R.sub.2 is H or CH.sub.3.
A method of treating malaria by administering to a host in need thereof an antimalarial effective amount of the compound having the formula ##STR4## wherein R.sub.1 is H or OH, and R.sub.2 is H or CH.sub.3.
A method of treating rheumatoid arthritis by administering to a host in need thereof an antiarthritis effective amount of the compound having the formula ##STR5## wherein R.sub.1 is H or OH and R.sub.2 is H or CH.sub.3.
Dependencies are inferred from the claim text.