Antifungal 2-anilinothiazolines
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsRussell J. Baumann, Boyd L. Harrison
Life of this patent
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Abstract
Fungal infections of the skin and mucous membranes may be controlled by topical administration of a pharmaceutical composition comprising a N-(3- or 4-alkylphenyl)4,5-dihydro-2-thiazolamine.
Claims15
A method for the treatment of a fungal infection which comprises topical administration of an effective amount of a compound of formula ##STR5## wherein (a) R is a straight chain alkyl group having from 4 to 8 carbon atoms and R.sub.1 is hydrogen or (b) R is hydrogen and R.sub.1 is a straight chain alkyl group having from 5 to 8 carbon atoms, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
A composition for topical therapy of a fungal infection in a mammalian host which comprises an effective amount of a compound of the formula ##STR6## wherein (a) R is a straight chain alkyl group having from 4 to 8 carbon atoms and R.sub.1 is hydrogen or (b) R is hydrogen and R.sub.1 is a straight chain alkyl group having from 5 to 8 carbon atoms, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier selected from the group consisting of ointments, creams, lotions, gargles, douches, suppositories, tablets, tampons, and patches.
A compound of the formula ##STR7## wherein R is a straight chain alkyl group having from 6 to 8 carbon atoms or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.