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AssigneeTerumo Kabushiki Kaisha
InventorsToshio Wakabayashi, Hirokazu Hasegawa, Akihiro Ohta
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Novel pyrazine derivatives are disclosed. The compounds possess a potent platelet aggregation-inhibiting activity and are effective for preventing diseases caused by aggregation of the platelet, for example, myocardial infarction and cerebral thromobsis. Representative examples of the pyrazine derivatives includes 2,3-bis(p-chlorophenyl)-5-methylpyrazine, 2,3-bis(p-methoxyphenyl)-5-methylpyrazine, 2,3-diphenyl-5-benzylpyrazine, 2,3-diphenyl-5-(p-methoxybenzyl)pyrazine, 2,3-bis(p-methoxyphenyl)-5-isopropylpyrazine, 2,3-bis(p-methoxyphenyl)-5-(2-thienylmethyl)pyrazine and 2,3-bis(p-methoxyphenyl)-5,6-dimethylpyrazine. The pyrazine derivatives can be generally prepared by heating a benzil derivative and a 1,2-diaminoethane derivative to produce a dihydropyrazine derivative and heating the resulting compound with sulfur at 100.degree.-180.degree. C.
A pyrazine compound having the formula ##STR23## wherein X is independently selected from a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a di-lower alkyl-amino group, R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a lower alkyl group;
A pharmaceutical composition of matter for use in inhibiting aggregation in a mammal, said composition comprising an effective amount of the pyrazine compound having the formula ##STR24## wherein X is independently selected from a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a di-lower alkyl-amino group, R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a lower alkyl group;
A method for inhibiting the aggregation of platelets in a mammal, said method comprising administering to said mammal an effective amount of a pyrazine compound to inhibit aggregation of platelets, said pyrazine derivative having the formula ##STR25## wherein X is independently selected from a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a di-lower alkyl-amino group, R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a lower alkyl group;
A method for treating a disease caused by aggregation of platelets in a mammal, said method comprising administering a therapeutically effective amount of the pyrazine compound to a mammal possibly afflicated with said disease, said pyrazine derivative having the formula ##STR26## wherein X is independently selected from a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a di-lower alkyl-amino group, R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a lower alkyl group;
Dependencies are inferred from the claim text.