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US 4,788,196 AGranted
Phenyl piperazine anti-arrhythmia agents
AssigneePfizer Inc.
InventorsPeter E. Cross, Roger P. Dickinson
Life of this patent
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Abstract
A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.
Claims10
A compound of the formula:
- ##STR11## or a pharmaceutically acceptable salt thereof, wherein
- R is R.sup.3 SO.sub.2 NH--, R.sup.3 CONH--. R.sup.1 R.sup.2 NSO.sub.2 --, or
- R.sup.1 R.sup.2 NCO--;
- R.sup.1 and R.sup.2 are each independently H or C.sub.1 -C.sub.4 alkyl;
- R.sup.3 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl or NR.sup.1 R.sup.2 ;
- and
- "Het" is 2, 3 or 4-pyridyl optionally substituted by one or more substituents each independently selected from C.sub.1 -C.sub.4 alkyl and NH.sub.2 ;
- or 2-imidazolyl optionally substituted by one or more C.sub.1 -C.sub.4 alkyl groups.
5 more elements
Dependencies are inferred from the claim text.