1-aryloxy-3-(substituted alkylamino)-2-propanols, pharmaceutical compositions and use
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, Gerald S. Ponticello
Life of this patent
Estimating the term…
Abstract
The 1-aryloxy-3-(substituted alkylamino)-2-propanols of this invention and their pharmaceutically acceptable salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and, antianginal agents.
Claims6
A compound of structural formula ##STR34## or a pharmaceutically acceptable salt thereof, wherein:
- Y is a 6-membered nitrogen containing heterocycle selected from morpholino, piperazino or N-C.sub.1-3 alkyl-piperazino;
- R.sup.1 is hydrogen;
- R.sup.2 is hydrogen;
- R.sup.3 is cyano, and
- n is 2, 3 or 4.
A pharmaceutical .beta.-blocking composition comprising a pharmaceutical carrier and an effective .beta.-blocking amount of a compound of structural formula:
- ##STR35## or a pharmaceutically acceptable salt thereof, wherein:
- Y is A 6-membered nitrogen containing heterocycle selected from morpholino, piperazino or N-C.sub.1-3 alkyl-piperazino;
- R.sup.1 is hydrogen;
- R.sup.2 is hydrogen;
- R.sup.3 is cyano, and
- n is 2, 3 or 4.
A method of treatment with a .beta.-blocker which comprises the administration to a patient in need of such treatment of an effective .beta.-blocking amount of a compound of structural formula:
- ##STR36## or pharmaceutically acceptable salt thereof, wherein Y is a 6-membered nitrogen containing heterocycle selected from morpholino, piperazino or N-C.sub.1-3 alkyl-piperazino;
- R.sup.1 is hydrogen;
- R.sup.2 is hydrogen;
- R.sup.3 is cyano, and
- n is 2, 3 or 4.
Dependencies are inferred from the claim text.