2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use

A compound of structural formula:

• ##STR40## or an ophthalmologically or pharmaceutically acceptable salt thereof, wherein:
• X is hydrogen, chloro, bromo or fluoro, C.sub.1-3 alkyl, hydroxy or C.sub.1-3 alkoxy;
• and
• R is:
• ##STR41## wherein R.sup.5 and R.sup.6 are independently:
• (a) hydrogen,
• (b) C.sub.1-18 alkyl, either straight or branched chain,
• (c) C.sub.3-6 cycloalkyl,
• (d) C.sub.3-6 cycloalkyl-C.sub.1-3 alkyl,
• (e) aryl-C.sub.1-3 alkyl wherein the aryl group is phenyl or naphthyl and is either unsubstituted or substituted with one or more of chloro, bromo, fluoro, C.sub.1-3 alkyl or C.sub.1-3 alkoxy,
• (f) ##STR42## wherein R.sup.7 is (i) C.sub.1-18 alkyl, either straight or branched chain,
• (ii) aryl as previously defined, either unsubstituted or substituted with one or more of chloro, bromo, fluoro, C.sub.1-3 alkyl, or C.sub.1-3 alkoxy,
• (iii) aryl-C.sub.1-3 alkyl wherein the aryl group is as previously defined and is either unsubstituted or substituted with one or more of chloro, bromo, fluoro, C.sub.1-3 alkyl or C.sub.1-3 alkoxy,
• (iv) amino-C.sub.1-18 alkyl either straight or branched chain;
• or
• (g) R.sup.5 and R.sup.6 if lower alkyl, are joined together directly or through a heteroatom selected from O or N to form a 5 or 6-membered heterocycle selected from pyrrolidine, piperidine, morpholine, and piperazine.