1,3-dithiolano-, 1,4-dithiino- and 1,4-dithiepino[2,3-C]pyrrole derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsKentaro Hiraga, Yoshiaki Saji
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Abstract
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S-- (l is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m -- (m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychoromatic disease and anxiety neurosis.
Claims9
A compound of the formula ##STR152## wherein X is a cyclic group of the class consisting of phenyl, naphthyl, pyridyl, pyridazinyl, pyrazinyl, pyrimidinyl, quinolyl, naphthyridinyl, thiazolyl, benzothiazolyl or C.sub.3-7 cycloalkyl, which cyclic group is attached through a carbon atom thereof and is unsubstituted or substituted by one halogen atom or C.sub.1-4 alkoxy group;
- Y is --COOH, --COOR.sup.1 or --CO--NR.sup.2 R.sup.3,
- wherein R.sup.1 is C.sub.1-4 alkyl, phenyl-C.sub.1-4 alkyl or phenyl, and wherein R.sup.2 and R.sup.3 are the same or different members of the class consisting of hydrogen, C.sub.1-4 alkyl, phenyl-C.sub.1-4 alkyl, phenyl, thiazolyl or benzothiazolyl, which are unsubstituted or substituted by a member of the class consisting of halogen, hydroxyl, C.sub.1-4 alkoxy, C.sub.2-5 alkoxycarbonyl and di-C.sub.1-4 alkylamino, or wherein NR.sup.2 R.sup.3 is a cyclic group of the class consisting of pyrrolidinyl, piperidino, hexahydroazepinyl, piperazinyl, morpholino or thiazolidinyl, which cyclic group is unsubstituted or substituted by a member of the class consisting of hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, C.sub.2-5 alkoxycarbonyl, phenyl-C.sub.1-4 alkyl, phenyl, piperidino and pyridyl;
- and l is 1, 2 or 3;
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.