2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds

Abstract

Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula ##STR1## wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo(lower)alkyl; Y is CH or N; Q is ##STR2## W is --NR.sub.5 --, --O--, --S(O).sub.n --; X is NO.sub.2, NR.sub.6 R.sub.7 or COR.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or (C.sub.2 -C.sub.6) alkanoyl; R.sub.6 and R.sub.7 are independently hydrogen, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhalo loweralkyl, (C.sub.2 -C.sub.6)alkanoyl lower alkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-trirazol-4-yl or R.sub.6 and R.sub.7 taken together with the nitrogen atom in NR.sub.6 R.sub.7 form substituted or unsubstituted heterocyclyl, said heterocyclyl substituents being (C.sub.2 -C.sub.6)alkanoyl, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhaloloweralkyl, (C.sub.2 -C.sub.6)alkanoyl, loweralkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-triazol-4-yl and R.sub.8 is lower alkyl, lower alkoxy, --NR.sub.1 R.sub.2, phenyl or phenyl substituted by one or more of halo, perhalo lower alkyl, lower alkyl, lower alkoxy, nitro, cyano or (C.sub.2 -C.sub.6)alkanoyl and p is 0, 1, 2, 3, 4 or 5 and n is 0, 1, or 2 and the stereochemical isomers thereof in racemic or optically active form; or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.