Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking
OwnerHoward I. Glazerinventor
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Abstract
Administering divided dose of oral Clonidine potentiated by an intramuscular tricyclic antidepressant alleviates the abstinence syndrome resulting from withdrawal of nicotine by smoking cessation. Patient response to the Clonidine/tricyclic serves as the basis for titrating the dosages of transdermal Clonidine and oral buspar administered daily for two weeks following the office visit. Behavioral counseling, supported by written and audio materials on diet, nutrition, exercise, stress management, and habit control, are provided to the patient. Following up support groups are also made available.
Claims42
A method for treating cigarette smoking withdrawal symptoms of a nicotine-habituated patient comprising the following steps:
- a. administering to said patient, a predetermined initial dosage of clonidine hydrochloride;
- b. simultaneously with step a., hereinabove, administering a imipramine derivative to potentiate the blocking effect of the clonidine hydrochloride;
- c. administering during the initial smoking cessation period successive daily treatment dosages of clonidine hydrochloride;
- d. simultaneously with step c., hereinabove, for relief of withdrawal symptoms administering successive daily treatment dosages of one of a specific subclass of anxiolytic substances selected from the group consisting of benzodiazepines, azospirodecanediones, and meprobamates.
- whereby the withdrawal symptoms experienced upon cessation of smoking are relieved.
A method for treating cigarette smoking withdrawal nicotine-habituated patient comprising the following steps:
- a. administering to said patient a predetermined initial dosage of clonidine;
- b. simultaneously with step a., hereinabove, administering an imipramine derivative to potentiate the blocking effect of the clonidine, said step further comprising the substeps of:
- (1) preparing an injectible sterile solution of the imipramine derivative in water with dextrose and preservatives;
- (2) injecting the solution, described in substep
- b.(1) above, intramuscularly into the patient;
- c. repeating the initial dosage of clonidine as described in step a., hereinabove;
- d. administering during the next successive smoking cessation period a daily treatment dosage of clonidine;
- and,
- e. simultaneously with step d., hereinabove, for relief of withdrawal symptoms administering successive daily treatment dosages of an one of a specific subclass of anxiolytic substances selected from the group consisting of benzodiazepines, azospirodecanediones, and meprobamates.
- whereby the withdrawal symptoms experienced upon cessation of smoking are relieved.
A method for treating cigarette smoking withdrawal symptoms of a nicotine-habituated patient comprising the following steps:
- a. orally administering to said patient, a predetermined initial dosage of clonidine hydrochloride;
- b. simultaneously with step a., hereinabove, administering a dosage of amitriptyline hydrochloride to potentiate the blocking effect of the clonidine, said step further comprising the substeps of:
- (1) preparing an injectible sterile solution of the amitriptyline hydrochloride in water with dextrose and preservatives;
- (2) injecting the solution, described in substep
- b.(1) above, intramuscularly into the patient;
- c. repeating the initial dosage of clonidine hydrochloride as described in step a., hereinabove;
- d. administering during the next successive smoking cessation period a daily treatment dosage clonidine hydrochloride;
- and,
- e. simultaneously with step d., hereinabove, administering successive daily treatment dosages of buspirone;
- to thereby relieve withdrawal symptoms;
- and,
- whereby the withdrawal symptoms experienced upon cessation of smoking are relieved.
Dependencies are inferred from the claim text.