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US 4,788,188 AGranted
Quinolylglycinamide derivatives, the process for preparation thereof and their therapeutic application as psychotropic drugs
AssigneeSanofi
InventorsJean-Claude Vernieres, Etienne Mendes, Michel Morre, Peter Keane, Jacques Simiand
Life of this patent
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Abstract
The present invention relates to new quinolylglycinamide derivatives corresponding to the following general formula: ##STR1## The invention also relates to a process for preparing these compounds and their therapeutic application as a psychotropic agent.
Claims10
A quinolylglycinamide compound having a quinoline nucleus, said compound having the formula:
- ##STR27## in which R.sub.1 and R.sub.2 are each, independently of each other, hydrogen or a lower alkyl group, or R.sub.1 is an alkyl group and R.sub.2 is a cyclohexyl group, a phenyl group, a benzyl group, a chlorophenyl group, or R.sub.1 and R.sub.2 form with the nitrogen atom to which they are directly attached a pyrrolidino, a piperidino or a homopiperidino, all of which can be substituted with a C.sub.1 -C.sub.4 alkyl;
- R.sub.3 is hydrogen, a hydroxyl group, a C.sub.1 -C.sub.4 alkyl or alkoxy group, a phenoxy group, a benzyloxy group, a phenoxy group, or a benzyloxy group, or R.sub.3 denotes a group (--NH--R.sub.5), in which R.sub.5 is hydrogen, a lower alkyl or phenyl group;
- R.sub.4 is hydrogen or a lower alkyl group;
- and
- X is is hydrogen, a halogen, a C.sub.1 -C.sub.4 alkyl group, a cyclohexyl group, a C.sub.1 -C.sub.4 alkoxy group, a nitro group, a trifluoromethyl group, or a methylthio group;
- or the addition salts of said quinolylglycinamide compound with pharmaceutically acceptable inorganic or organic acids or, when R.sub.3 denotes OH, the salts with pharmaceutically acceptable alkali metal bases or organic bases.
3 more elements
Dependencies are inferred from the claim text.