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US 4,788,187 AGranted
Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical composition and use
AssigneeRorer Pharmaceutical Corporation
InventorsDonald E. Kuhla, Henry F. Campbell, William L. Studt
Life of this patent
Estimating the term…
Abstract
A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.
Claims10
A compound of the formula ##STR98## wherein:
- a is 1 or 2;
- b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen, sulfur, ##STR99## Z is ##STR100## or R.sub.1 is --NR.sub.5 R.sub.6,
- R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, lower alkyl, allyl, wherein aryl is phenyl or substituted phenyl, loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound of the formula ##STR101## wherein:
- b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen or sulfur;
- Z is ##STR102## R.sub.2, R.sub.3, and R.sub.4 are each independently hydrogen, lower alkyl, allyl, arylloweralkyl, wherein aryl is phenyl or substituted phenyl loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
3 more elements
A compound of the formula ##STR103## wherein:
- b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen or sulfur;
- Z is ##STR104## R.sub.2, R.sub.3, and R.sub.4 are each independently hydrogen, lower alkyl, allyl, arylloweralkyl, wherein aryl is phenyl or substituted phenyl loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.