US 4,788,182 A · Phosphatidyl compounds, processes for their manufacture, and their use

Abstract

Described are phosphatidyl compounds of the formula I ##STR1## in which R.sup.1 represents C.sub.3-14 -alkanoyl, benzoyl, the acyl radical of an .alpha.-aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the .alpha.-amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a .beta.-aminocarboxylic acid or an .alpha.- or .beta.-hydroxycarboxylic acid, T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen, Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy, W represents hydrogen, and Z represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C.sub.8-30 -carboxylic acid or is etherified by an aliphatic C.sub.8-30 -alcohol, or each of W and Z represents a hydroxymethyl group that is esterified by an aliphatic C.sub.8-30 -carboxylic acid or is etherified by an aliphatic C.sub.8-30 -alcohol, and their salts, and processes for their manufacture. The mentioned novel compounds, and structurally related compounds that are likewise described and that belong to the state of the art, are used for the propylaxis and treatment of viral infections.

Claims19

Dependent claims

A phosphatidyl compound of formula I ##STR11## wherein R.sup.1 is an alpha-amino-lower alkanoyl the alpha-amino group of which may be substituted by lower alkanoyl, by lower alkoxycarbonyl or by benzyloxycarbonyl and said alpha-amino-lower alkanoyl radical is substituted by phenyl or by 4-hydroxyphenyl;

T is NH that is unsubstituted or substituted by lower alkyl, or is oxygen;
Y is dimethylene which is unsubstituted or substituted by carboxy, lower alkoxycarbonyl, phenoxycarbonyl, benzyloxycarbonyl, benzhydryloxycarbonyl, carbamoyl or N-lower alkylcarbamoyl that is unsubstituted or is substituted in the lower alkyl moiety by carboxy or lower alkoxycarbonyl;
and
(a) W is hydrogen and
Z is 1,2-dihydroxyethyl, 2-hydroxyethyl, or hydroxymethyl wherein at least one of the hydroxy groups is esterified by an aliphatic C.sub.8 -C.sub.30 carboxylic acid or is etherified by an aliphatic C.sub.8 -C.sub.30 alcohol or
(b) each of W and Z is hydroxymethyl that is esterified by an aliphatic C.sub.8 -C.sub.30 carboxylic acid or etherified by an aliphatic C.sub.8 -C.sub.30 alcohol;
or a pharmaceutically acceptable salt thereof or a mixture of said pharmaceutically acceptable salt and said compound.

4 more elements

Dependencies are inferred from the claim text.

Phosphatidyl compounds, processes for their manufacture, and their use

Life of this patent

Phosphatidyl compounds, processes for their manufacture, and their use

Life of this patent

Abstract

Claims19