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US 4,788,181 AGranted
5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJohn S. Driscoll, Victor E. Marquez, Chong-Ho Kim, James A. Kelley
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Abstract
5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted 2',3'-dideoycytidine compounds have been found to be effective against HTLV-III/LAV virus.
Claims8
A 5-substituted 2',3'-dideoxycytidine compound of the formula:
- ##STR5## wherein X is selected from the group consisting of bromine and fluorine.
A phosphorylated compound of the formula ##STR6## wherein X is selected from the group consisting of bromine and fluorine.
Dependencies are inferred from the claim text.