Drug delivery system
AssigneeState of Israel, Represented by Prime Minister's Office Israel Institute for Biological Research
InventorsAbraham Fisher, Drora Levy, Michael Y. Spiegelstein, Jacob Grunwald, Aharon Levy, Moshe Kushnir
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Abstract
There is provided a composition for the transdermal application of basic drugs which have a high specific activity. The drug is provided in combination with a fatty acid having a low molecular weight. Amongst others, the delivery system is suited for cholinergic and anticholinergic basic drugs. The compositions can be supported by a pad, bandage or the like. It is one of the advantages of the compositions of the invention that a prolonged effect can be obtained, with an essentially constant therapeutic level of the active ingredient.
Claims5
A pharmaceutical composition for transdermal application of, as the active ingredient, a drug of high intrinsic specific activity comprising in combination said active ingredient and a low molecular weight C.sub.2 -C.sub.10 fatty acid, said active ingredient being a cholinergic or anticholinergic agent selected from the group consisting of physostigmine, tetrahydroaminoacridine, arecoline, oxotremorine, pilocarpine, acceclidine, scopolamine, atropine, benztropine, aprophen, artane, trihexyphenidyl and benactyzine.
Dependencies are inferred from the claim text.