Non-adsorptive, semipermeable filtration membrane
AssigneeW. R. Grace & Co.
InventorsMarc E. Parham, Karen E. Milligan
Life of this patent
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Abstract
Disclosed is a protein non-adsorptive semipermeable filtration membrane and a process for producing the same. Said membrane, which comprises an interpenetrating polymer network, is prepared from a casting solution comprising a prepolymer polymerizable upon contact with a coagulating liquid, a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, and solvent.
Claims41
A self-supported substantially protein non-adsorptive, semipermeable filtration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) an isocyanate capped urethane prepolymer polymerizable upon contact with a coagulating liquid, (ii) a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
A substantially protein non-adsorptive, anisotropic, semipermeable, hollow fiber ultrafiltration membrane consisting essentially of an interpenetrating polymer network prepared from a casting solution comprising (i) a hydrophilic isocyanate capped polyethylene glycol urethane prepolymer, (ii) a substantially water-insoluble polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and (iii) solvent.
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network which comprises the following steps:
- (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support;
- (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer;
- and
- (c) recovering the membrane produced in step b from the support.
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetration polymer network which comprises the following steps:
- (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyaate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer polysulfone and cellulose acetate, and solvent;
- (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorption prepolymer is polymerizable upon contact and which is a non-solvent for the polymer and prepolymer;
- and
- (c) recovering the membrane produced in step b.
A method for producing a self-supported substantially protein non-adsorptive, semipermeable, anisotropic, filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps:
- (a) casting a solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent on a support;
- (b) immersing the supported film in a coagulation bath comprising a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine;
- and
- (c) recovering the membrane produced in step b from the support.
A method for producing a substantially protein non-adsorptive, semipermeable, anisotropic, hollow fiber filtration membrane consisting essentially of an interpenetrating polymer network, which comprises the following steps:
- (a) preparing a casting solution comprising a substantially protein non-adsorptive isocyanate capped urethane prepolymer, a polymer that will not react readily with the prepolymer, said polymer selected from the group acrylonitrile-vinyl chloride copolymer, polysulfone and cellulose acetate, and solvent;
- (b) spinning said casting solution through a spinneret for hollow fiber production while simultaneously introducing through the central aperture of said spinneret a coagulating liquid with which the protein non-adsorptive prepolymer is polymerizable upon contact, which is a non-solvent for the polymer and prepolymer, and which comprises up to about 25% polyamine;
- and
- (c) recovering the membrane produced in step b.
Dependencies are inferred from the claim text.