Resolution of enantiomers of 2-(4-aryloxyphenoxy) propionic acids by liquid chromatography with a chiral eluent
AssigneeThe Dow Chemical Company
InventorJohn W. Russell
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Abstract
A method for the effective chromatographic resolution and analysis of the enantiomers of 2-(4-aryloxyphenoxy)propionic acids which comprises dissolving a 2-(4-aryloxyphenoxy)propionic acid in a suitable solvent, injecting the solution into a liquid chromatographic system and eluting the components from the column using an eluent contain R-(-)- or S-(+)-2-pyrrolidinemethanol and an alkanoic acid in a suitable solvent.
Claims7
A method for the effective chromatographic resolution and analysis of the enantiomers of 2-(4-aryloxyphenoxy)propionic acids of the formula ##STR15## wherein Ar is an unsubstituted or substituted aryl or heterocyclic ring system which comprises dissolving the 2-(4-aryloxyphenoxy)propionic acid in a solvent selected from the group consisting of chlorinated hydrocarbons and admixtures thereof with aliphatic alcohols, injecting the solution into a liquid chromatographic system and eluting the column with an eluent containing R-(-)- or S-(+)-2-pyrrolidinemethanol and an alkanoic acid in said solvent.
Dependencies are inferred from the claim text.