Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines
AssigneeThe Dow Chemical Company
InventorJohn W. Russell
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Abstract
A method for the chromatographic resolution and analysis of the enantiomers of 2-(phenyl or phenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof which comprises converting a racemic or partially resolved mixture of said 2-(phenyl or phenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof to a pair of diastereomeric 2-amino-1-alkanol derivatives by reaction with an optically active 2-amino-1-alkanol, and analyzing the diastereomeric mixture by gas chromatography.
Claims6
A method for the chromatographic resolution and analysis of the enantiomers of 2-(4-(alkyl or aryl)oxyphenoxy)propionic acids of the formula ##STR22## wherein R is H, C.sub.1 -C.sub.4 alkyl or Ar, m and n are independently 0 or 1,
- and Ar is an unsubstituted or substituted phenyl pyridinyl or quinoxalinyl ring system
- or the C.sub.1 -C.sub.4 alkyl esters thereof which comprises converting a racemic or partially resolved mixture of said 2-(4-(alkyl or aryl)oxyphenoxy)propionic acid or C.sub.1 -C.sub.4 alkyl ester thereof to a pair of diastereomeric 2-amino-1-alkanol derivatives by reaction with an optically active 2-amino-1-alkanol under conditions that avoid racemization and analyzing the diastereomeric mixture by gas chromatography.
Dependencies are inferred from the claim text.