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US 4,786,725 AGranted
Solubilized platinum (II) complexes
AssigneeEngelhard Corporation
InventorsAlan R. Amundsen, Eric W. Stern
Life of this patent
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Abstract
There are described platinum-polyhydroxylated amine compounds which exhibit anti-tumor activity in mammalian species. The products are highly soluble in aqueous solutions and they may be administered either orally or in parenteral form.
Claims1
A compound having the formula:
- ##STR21## wherein A.sub.2 is a polyhydroxy substituted bidentate amine of the formula:
- ##STR22## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, C.sub.1-6 alkyl, or C.sub.1-6 mono or polyhydroxyalkyl provided that R.sub.1 and R.sub.2 taken together contain two or more hydroxyl groups, or
- A is a polyhydroxy substituted monodentate amine of the formula:
- R.sub.1 NH.sub.2
- wherein R.sub.1 is a carbohydrate moiety derived from glucose, fructose, galactose, sucrose, or lactose, and
- X is an anionic ligand selected from the group consisting of halide and carboxylate, or
- X.sub.2 is selected from the group consisting of dicarboxylate anion, sulfate, orthophosphate, pyrophosphate, and a combination of aquo and sulfate, orthophosphate, or pyrophosphate.
4 more elements
Dependencies are inferred from the claim text.