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US 4,786,644 AGranted
1-aryl-3-quinolinecarboxamide
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsEdward J. Glamkowski, R. Richard L. Hamer
Life of this patent
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Abstract
Novel 1-aryl-3-quinolinecarboxamides and 1-aryl-3-isoquinolinecarboxamides, processes for the preparation thereof, and methods for treating pain and inflammation utilizing compounds and compositions thereof are disclosed.
Claims53
A compound of the formula:
- wherein R.sup.1 and R.sup.2 are monovalent radicals independently selected from the group consisting of halogen, loweralkyl and loweralkoxy;
- R.sup.3 is a substituted or unsubstituted monovalent radical selected from the group consisting of phenyl, pyridyl, pyrimidyl, pyrazinyl, triazinyl, thiazolyl, thiadiazolyl, isoxazolyl, oxadiazolyl, quinolyl, and benzothiazolyl;
- and m and n are integers independently having values of zero or 1;
- the optical antipodes and pharmaceutically acceptable acid addition salts thereof.
1 more element
A compound of the formula:
- ##STR24## wherein R.sup.1 and R.sup.2 are monovalent radicals independently selected from the group consisting of halogen, loweralkyl and loweralkoxy;
- R.sup.3 is a substituted or unsubstituted monovalent radical selected from the group consisting of phenyl, pyridyl, pyrimidyl, pyrazinyl, triazinyl, thiazolyl, thiadiazolyl, isoxazolyl, oxadiazolyl, quinolyl, and benzothiazolyl;
- m and n are integers independently having values of zero or 1;
- and the dotted line is an optional bond;
- the optical antipodes and pharmaceutically acceptable acid addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.