US 4,786,643 A · Treatment of migraine, cluster headaches and trigeminal neuralgia

Abstract

A method of treatment of migraine, cluster headaches and trigeminal neuralgia, radiation or cytotoxic agent induced nausea and vomiting and/or cardiac arrhythmia in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 is C.sub.1-6 alkyl; R.sub.2 is amino or C.sub.1-7 acylamino; R.sub.3 is halo; one of R.sub.4 and R.sub.5 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl C.sub.1-3 alkyl, which phenyl moieties may be substituted by one or more substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CF.sub.3 or halogen; the other of R.sub.4 and R.sub.5 is hydrogen or C.sub.1-6 alkyl; p is 0 to 2; and q is 0 to 3.

Claims6

Dependent claims

A method of treatment of migraine, cluster headaches and trigeminal neuralgia, in mammals, including humans, which method comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

##STR3## wherein:
R.sub.1 is C.sub.1-6 alkyl;
R.sub.2 is amino or C.sub.1-7 acylamino;
R.sub.3 is halo;
R.sub.4 and R.sub.5 are both hydrogen;
p is 0 or 1;
and
q is 1.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

07/122,920Filed 19 Nov 1987 · division

Priority

GB 851584522 Jun 1985

Granted

22 Nov 1988

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/55
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 31/445
Non condensed pyridines; Hydrogenated derivatives thereof: non condensed piperidines, e.g. piperocaine
A61K 31/46
Having six-membered rings with one nitrogen as the only ring hetero atom: 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
A61P 1/08
Drugs for disorders of the alimentary tract or the digestive system: for nausea, cinetosis or vertigo; Antiemetics

Treatment of migraine, cluster headaches and trigeminal neuralgia

Life of this patent

Treatment of migraine, cluster headaches and trigeminal neuralgia

Life of this patent

Abstract

Claims6