Back to results
US 4,786,640 AGranted
2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acid aldose reductase inhibitors
AssigneeAmerican Home Products Corporation
InventorsJehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
Life of this patent
Estimating the term…
Abstract
Disclosed herein are 2,6-disubstituted-5-cyano-4-pyrimidinyloxyacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
Claims7
A compound of formula (I) ##STR21## wherein R.sup.1 is lower alkyl having 1 to 6 carbon atoms, cyclo(lower)alkyl having 3 to 6 carbon atoms, phenyl, halogen substituted phenyl, phenylmethyl, naphthalenyl, halogen substituted naphthalenyl, or thienyl;
- R is --S--R.sup.2 wherein R.sup.2 is lower alkyl having 1 to 6 carbon atoms, lower cycloalkylmethyl having 4 to 7 carbon atoms, phenylmethyl, or halogen substituted phenylmethyl;
- or R is R.sup.3 wherein R.sup.3 is lower alkyl having 1 to 4 carbon atoms, phenyl, or 1-naphthalenylmethyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.