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US 4,786,638 AGranted
2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acid aldose reductase inhibitors
AssigneeAmerican Home Products Corporation
InventorsJehan F. Bagli, John W. Ellingboe, Thomas R. Alessi
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Abstract
Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
Claims9
The compounds of formula (I) ##STR33## wherein R.sup.1 is lower alkyl having 1 to 3 carbon atoms, cyclo(lower)alkyl having 3 to 6 carbon atoms, naphthalenyl, or halogen substituted anphthalenyl;
- R is --SR.sup.2 wherein R.sup.2 is lower alkyl having 1 to 6 carbon atoms, phenylmethyl, halogen substituted phenylmethyl, cyclohexylmethyl;
- or R is ##STR34## wherein R.sup.3 is hydrogen, and R.sup.4 is phenylalkyl, pyridinylmethyl, cyclohexylmethyl;
- or R.sup.3 and R.sup.4 are joined together to form piperidinyl, 4-phenylmethylpiperidinyl, or N-phenylmethylpiperazinyl;
- or R is R.sup.5 wherein R.sup.5 is lower alkyl hvaing 1 to 3 carbon atoms, phenyl, or naphthalenylmethyl;
- and the pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.