Thiazino-benzimidazoles and their use as antiulcer agents

A pharmaceutical composition for treating ulcers or hypersecretion comprising an antiulcer/antihypersecretion effective amount of a compound of formula ##STR23## or a pharmaceutically acceptable salt thereof wherein --B--B.sup.1 --represents a chain or formula

• --CR.sup.5 =CR.sup.6 -- (Ib)
• --CHR.sup.5 --CR.sup.6 .dbd. [--(CHR.sup.5).sub.n --CR.sup.6 =](Ic)
• R represents a phenyl, naphthyl, pyridyl, thienyl, furyl, thiazolyl, quinolyl, isoquinolyl or indolyl group, each optionally substituted by one or more substituents the same or different selected from lower alkylthio, lower alkyl, lower alkoxy, halogen, alkanoyloxy of 2 to 7 carbon atoms, lower alkoxycarbonyl, halolower alkyl, hydroxy, cyano, amino, mono- or diloweralkyl amino, lower alkanoylamino, carboxy, carboxyloweralkyl, hydroxylower alkyl, carbamoyl, carbamoyloxy, lower alkyl-carbonyl, benzoly, naphthoyl, (loweralkoxy) lower alkoxy, 1-piperidinyl, 4-morpholinyl, 4-loweralkylpiperazinyl, 1-pyrrolidinyl, OR.sup.8, SR.sup.8, phenyl and phenyl substituted by one or more substituents as hereinbefore defined excepting phenyl;
• (where R.sup.8 is C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, phenyl, naphthyl, phenylalkyl, naphthylalkyl or phenyl or naphthyl or phenylalkyl or naphthylalkyl each carrying from 1 to 3 substituents on the aryl selected from lower alkyl, halogen, nitro, haloloweralkyl, hydroxy and lower alkoxy),
• R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, or a substituent as mentioned above in connection with the group R,
• R.sup.5 and R.sup.6 independently represent hydrogen or lower alkyl;
• and m is 0 or 1, and a pharmaceutically acceptable carrier.

A method of treating ulcers or hypersecretion in a mammal which method comprises administering to said mammal in need of such treatment an antiulcer/antihypersecretion effective amount of a compound of formula ##STR24## or a pharmaceutically acceptable salt thereof, wherein --B--B.sup.1 --represents a chain of formula

• --CR.sup.5 .dbd.CR.sup.6 -- (Ib)
• --CHR.sup.5 --CR.sup.6 .dbd. [--(CHR.sup.5).sub.n --CR.sup.6 =](Ic)
• R represents a phenyl, naphthyl, pyridyl, thienyl, furyl, thiazolyl, quionolyl, isoquinolyl or indolyl group, each optionally substituted by one or more substituents the same or different selected from lower alkythio, lower alkyl lower alkoxy, halogen, alkanoyloxy of 2 to 7 carbon atoms, lower alkoxycarbonyl, haloloweralkyl, hydroxy, cyano, amino, mono- or diloweralkyl amino, lower alkanoylamino, carboxy, carboxylower alkyl, hydroxylower alkyl, carbamoyl, carbamoyloxy, loweralkyl-carbonyl, benzoyl, benzoyl, naphthoyl, (loweralkoxy lower alkoxy, 1-piperidinyl, 4-morpholinyl, 4-lower alkylpiperazinyl, 1-pyrrolidinyl, OR.sup.8, SR.sup.8, phenyl, and phenyl substituted by one or more substituents as hereinbefore defined excepting phenyl;
• (where R.sup.8 is C.sub.2 -C.sub.6 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, phenyl, naphthyl, phenylalkyl, naphthyalkyl or phenyl or naphthyl or phenyalkyl or naphthylalkyl each carrying from 1 to 3 substituents on the aryl selected from lower alkyl, halogen, nitro, haloloweralkyl, hydroxy and lower alkoxy),
• R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, or a substituent as mentioned above in connection with the group R;
• R.sup.5 and R.sup.6 independently represent hydrogen or lower alkyl;
• and m is 0 or 1.