Novel benzothiazine derivatives

A pharmaceutical composition comprising (i) a pharmaceutical carrier and (ii) a platelet anti-aggregative effective amount of a compound of the formula (I):

• ##STR12## wherein R.sup.1 is one or more groups selected from those consisting of hydrogen, lower alkyl, halogen, nitro, hydroxy, lower alkoxy, lower alkanoyloxy, amino, lower alkylamino and lower alkoxycarbonylox;
• R.sup.2 is hydrogen, lower alkyl or (C.sub.3 -C.sub.6)cycloalkyl;
• R.sup.3 is one or more groups selected from those consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, lower alkylenedioxy wherein the oxygens are on adjacent positions, lower alkanoyloxy, lower alkanoyl, amino, lower alkylamino, lower alkanoylamino and lower alkoxycarbonyloxy or ##STR13## R.sup.4 is hydrogen or lower alkyl;
• A and B are same or different and are lower alkylene having 1 to 6 carbon atoms;
• and
• n is 3 to 4.

A pharmaceutical composition comprising (i) a pharmaceutical carrier and (ii) a calcium antagonistic effective amount of a compound of the formula (I):

• ##STR14## wherein R.sup.1 is one or more groups selected from those consisting of hydrogen, lower alkyl, halogen, nitro, hydroxy, lower alkoxy, lower alkanoyloxy, amino, lower alkylamino and lower alkoxycarbonyloxy;
• R.sup.2 is hydrogen, lower alkyl or (C.sub.3 -C.sub.6) cycloalkyl;
• R.sup.3 is one or more groups selected from those consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, lower alkylenedioxy wherein the oxygens are on adjacent positions, lower alkanoyloxy, lower alkanoyl, amino, lower alkylamino, lower alkanoylamino and lower alkoxycarbonyloxy or ##STR15## R.sup.4 is hydrogen or lower alkyl;
• A and B are same or different and are lower alkylene having 1 to 6 carbon atoms;
• and
• n is 3 to 4.