Long shelf life tablet containing hydrolysis prone active ingredient
AssigneeBoehringer Ingelheim GmbH
InventorMichael Schmidt
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Abstract
This invention relates to a pharmaceutical tablet containing active substance prone to hydrolysis and having a long shelf life which comprises (1) one or more layers free from active substance and (2) a layer containing said active substance in a concentration sufficient to inhibit hydrolysis.
Claims7
A long shelf life pharmaceutical layer tablet comprising a hydrolysis-prone active ingredient, said tablet being composed of (1) one or more placebo layers, each consisting of a mixture of conventional tablet making excipients devoid of said active ingredient, and (2) one verum layer consisting of a mixture of conventional tablet making excipients and said hydrolysis-prone active ingredient, said active ingredient being present in said verum layer in a concentration sufficient to inhibit hydrolysis thereof during storage.
A long shelf life pharmaceutical layer tablet comprising a hydrolysis-prone active ingredient, said tablet being composed of (1) one to two placebo layers, each consisting of a mixture of conventional tablet making excipients devoid of said active ingredient, and (2) one verum layer consisting of a mixture of conventional tablet making excipients and said hydrolysis-prone ingredient, said active ingredient being present said verum layer in a concentration sufficient to inhibit hydrolysis thereof during storage, the total weight of the tablet being at least 40 mg.
Dependencies are inferred from the claim text.